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George Siegel on Does Aβ Normally Rein in Excited Synapses?

COMMENT The physiologic effect of Abeta in depressing excitatory transmission in hippocampal slices as reported by Kamenetz et al may be due to the effect of Abeta in causing depletion of presynaptic SNAP-25 from hippocampus in transgenic mice, since SNAP-25 is ...

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