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Joshua Shulman on Tau, Speckle Wrecker, Disrupts the Nuclear Home

COMMENT This interesting work adds to a growing number of reports that tau can co-aggregate with RNA and RNA-binding proteins. Lester and colleagues further show that this leads to disruptions in nuclear compartments, such as speckles, that have critical roles in ...

Joshua Shulman on Jumping Genes Rampant in Tau Flies

COMMENT In this independent and insightful study combining investigations in fruit flies and human postmortem tissue, Dr. Frost’s team reports results that agree with, and significantly add to, our recent findings that tau pathology can modulate the activity of ...

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