Jie Shen on Pathogenic Presenilin Mutations Generate Aβ43

COMMENT I would like to start my comment by stating the obvious—science is about finding the truth, and ultimately the truth prevails. Since our response paper published in Neuron has already thoroughly addressed the issues, including the technical limitations ...

Jie Shen on Recycling endosomes supply AMPA receptors for LTP.

COMMENT This new study from the Ehlers and Kauer groups provides important new insight into the molecular mechanisms underlying the expression of long-term potentiation (LTP), the principal cellular model for learning and memory. Prior work has established that ...

Jie Shen on Target BACE: Better Than Ever?

COMMENT This is an interesting paper, and these mice are very useful for addressing a number of issues. The behavioral paradigms the authors chose to use are not the strongest learning and memory tests available; more robust and better established hippocampal ...

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