8 RESULTS
COMMENT I would like to start my comment by stating the obvious—science is about finding the truth, and ultimately the truth prevails. Since our response paper published in Neuron has already thoroughly addressed the issues, including the technical limitations ...
COMMENT The debate seems to miss the point—our genetic studies suggest that loss of presenilin’s essential functions is a more potent cause of neurodegeneration than accumulation of Aβ species. This conclusion is based on the findings that 1) loss of presenilin ...
COMMENT Based on our mouse genetic studies, which showed that conditional inactivation of presenilins in the mouse brain phenocopies the cardinal features of Alzheimer disease, namely dementia and neurodegeneration, I proposed in 2003 that FAD-linked PS mutations ...
COMMENT This is a very nice paper! Using a thorough, systematic approach, the authors found that cpg2, a gene they previously identified to be upregulated by kainic acid-induced seizures, encodes a protein localized specifically to an endocytic zone within spines ...
COMMENT This new study from the Ehlers and Kauer groups provides important new insight into the molecular mechanisms underlying the expression of long-term potentiation (LTP), the principal cellular model for learning and memory. Prior work has established that ...
COMMENT This study confirms some of our results. It reproduces the neurodegeneration phenotype we saw in an independently generated presenilin double conditional KO. Feng et al. report an increase in apoptosis; we tested for this but did not see it in our mice. ...
COMMENT This is an interesting paper in that it connects CBP and androgen receptor to the expression of VEGF. (Evidence that CBP regulates VEGF expression and for the connection between CBP and androgen receptor already existed.) It is curious that the authors ...
COMMENT This is an interesting paper, and these mice are very useful for addressing a number of issues. The behavioral paradigms the authors chose to use are not the strongest learning and memory tests available; more robust and better established hippocampal ...
