14 RESULTS
COMMENT Selectivity of neuronal loss under disease conditions is still a mystery. In the present study, Zalocusky and colleagues attribute a key role to neuronal expression of APOE in regulating MHC-I expression, and thereby, selective neuronal vulnerability. ...
COMMENT For decades, cognitive deterioration occurring during aging was considered to be neuronal-centric, and thus was attributed solely to neuron exhaustion, dysfunction, or, in the extreme case, to neuronal loss. Over the last two decades, emerging studies ...
COMMENT Harnessing the peripheral immune system as a neuroprotective therapeutic approach to Alzheimer's disease: Discussion regarding pathways and mechanism Immunotherapy targeting the programmed death protein (PD)-1/PD-L1 pathway was shown to be effective ...
COMMENT With regard to Latta-Mahieu et al., 2018, I am confident that the three groups that published this paper would have been able to repeat the positive effect of anti-PD-1 antibody on plaque burden, if they had calibrated the antibody and the treatment ...
COMMENT The present study highlights the connection between cholesterol, the choroid plexus and immune-brain control communication. Yin et al. attribute a key role to APOE in controlling the choroid plexus (ChP), as a functional interface between the brain and ...
COMMENT We thank Richard Ransohoff for his insightful comments. We would like to clarify several points: 1. Indeed, plaque-associated macrophages have been known in AD since initial pathological descriptions. However, this is the first study that describes the ...
COMMENT This paper by Cooper-Knock and colleagues describes an extremely important study in understanding ALS, and in searching for prognostic biomarkers of ALS progression. Overall, the work emphasizes that ALS, not only in animal models but also in patients, is ...
COMMENT In this elegant and important study, Samuel E. Marsh and colleagues demonstrate that deficiency in the adaptive arm of the immune system exacerbates pathology in an Alzheimer’s disease mouse model. While the hypothesis that adaptive immunity plays a role ...
COMMENT It is becoming increasingly clear that circulating immune cells play a role in Alzheimer’s disease (AD) pathophysiology. These cells can play a direct role in affecting the local neuroinflammatory process associated with AD, as well an indirect role via ...
COMMENT We agree with Appel's work that recruitment of Tregs to the spinal cord parenchyma is beneficial in ALS. Yet it is important to note that the optimal way to bring more Tregs to the CNS may not be by increasing their levels in the circulation; on the ...
COMMENT It is becoming widely accepted that CNS-infiltrating immune cells play a key role in fighting neurodegenerative conditions. Nevertheless, in most chronic neurodegenerative diseases, the recruitment of these cells into the CNS seems to be insufficient or ...
COMMENT Mutations in TDP-43, a DNA/RNA-binding protein, cause an inherited form of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). The work by J.P. Julien and colleagues very elegantly shows a linkage between the abnormal regulation of TDP-43 ...
COMMENT This article elegantly shows the strength of transcriptome analysis for the rapid discovery of a new drug. In this study, the authors identified the therapeutic potential of modulating CD40L in ALS using an animal model. Through transcriptome analysis, ...
COMMENT Reply by Michal Schwartz. Studies over the last five years have provided evidence that the body’s ability to withstand injurious conditions in the CNS, regardless of their primary cause, is dependent on the peripheral immune system. Our group showed, for ...
