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Wiep Scheper on Does Tau Kill Neurons by Way of Necroptosis?

COMMENT This extensive and well-performed study by Koper et al. shows an interesting novel feature of GVBs, as their core is immunopositive for necrosomes. As the authors and commentators indicate, caution is warranted with mechanistic interpretation based on ...

Wiep Scheper on Aβ Assault on Neurons Targets ER, Calcium

COMMENT Our lab previously reported activation of the UPR in AD neurons (Hoozemans et al., 2005). In the current paper, Ferreiro et al. show induction of BiP levels, as well as decreased pro-caspase-12 levels induced by Aβ1-40. This may indicate that the ER ...

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