9 RESULTS
COMMENT There is compelling evidence that Aβ generated from the sequential cleavage of APP by β-secretase and PS/γ-secretase is both secreted at the extracellular space and accumulated intracellularly in cultured cells and brains from transgenic mouse models and ...
COMMENT This is an interesting study that provides evidence that Aβ-induced memory deficits in 3xTg-AD transgenic mice are mediated through deregulation of the transcription factor CREB. The authors show reduced levels of phosphorylated CREB, a required step for ...
COMMENT In a new study from Jie Shen’s lab, C. Zhang et al. provide compelling evidence that presenilins (PS) located at presynaptic terminals regulate neurotransmitter release during synaptic transmission. By using new engineered mice with specific deletion of ...
COMMENT Jie Shen and Ron Kelleher’s PNAS Perspective summarizes experimental data from several laboratories suggesting a presenilin loss-of-function mechanism in Alzheimer disease. This hypothesis is strongly supported by the following experimental evidence: 1. ...
COMMENT The mechanisms by which FAD-linked PS mutations cause memory loss and neurodegeneration are by far unclear. The paper by Bart De Strooper and collaborators supports a large number of publications describing a reduced activity of PS mutations in the ...
COMMENT Kang and colleagues described a new role of presenilins on the highly conserved ERK signaling cascade. Specifically, these authors demonstrate that loss of presenilins alters the expression, degradation, and function of the tyrosine kinase receptor PDGF, ...
COMMENT Notch signaling is a highly conserved pathway that plays essential roles in cell proliferation and differentiation. It is unclear, however, whether Notch-1 signaling does participate in cellular events leading to neurodegeneration. In this, S. J. DeArmond ...
COMMENT Notch signaling plays a crucial role on cell fate specification during neuronal development in C. elegans, Drosophila and vertebrates. In the adult brain, however, the role of Notch signaling on neuronal morphology and function is largely unknown. Now, ...
COMMENT Feng et al. describe cortical degeneration in the forebrain of mice lacking the Alzheimer’s disease genes presenilin (PS) 1 and 2. The mice help to define essential roles of presenilins in the maintenance of brain function. These results confirm previous ...
