15 RESULTS
COMMENT In agreement with several of the statements above, the clinical trial failure of BACE does not take away the importance of Aβ and senile plaques as key initiators of AD-associated dementia. I will emphasize that these disappointments are due to toxicity ...
COMMENT Let us hope that prodromal AD will benefit from verubecestat treatment. A problem with even this relatively early stage of disease is that Aβ may have already accumulated, which will make a negative study difficult to interpret. This confound is in ...
COMMENT It is really sad and sudden to lose a valuable and always cooperative colleague. sambak 0 ...
COMMENT I would like to point out that loss and gain of function are really definitions dependent on the phenotype being assessed. We have always held that presenilin mutations represented an impairment of γ-secretase activity, and recognized a parallel between ...
COMMENT Inhibition of α-secretase does not affect BACE1 processing in neuroblastoma cells expressing endogenous APP (Gandhi et al., 2004). Thus, the two pathways don't appear to compensate for each other, but appear to occur in independent compartments. ...
COMMENT This is a truly exciting advance. While the small RNA world has captured the attention of the field, the global spicing failure is very novel and has been ignored since the days of KPI containing APP forms. It is curious that the authors saw a large ...
COMMENT The controversy and research opportunities that Larry started on the role of cholesterol in AD pathogenesis lives on. He was also a really nice and friendly person. It is very sad to see him go. sambak 0 ...
COMMENT The binding of amyloid by RAGE has been an interesting development that has long been waiting to be exploited. Unfortunately, initial efforts have not been successful in clinical trials. This multimodal drug has particularly exciting possibilities, as it ...
COMMENT This represents a careful and significant study with clean results. It probably explains why γsecretase loses activity in Triton-X100 and helps in a more thorough functional characterization of the enzyme. sambak 0 ...
COMMENT This is an exciting finding. sambak 0 ...
COMMENT It is impossible to give words to feelings under these conditions. Although my personal interactions with Ann were brief and periodic, they were extraordinarily memorable. She was kind, open and great for discussion. She will certainly be missed. Peter, I ...
COMMENT Great findings. sambak 0 ...
COMMENT This is a truly exciting study that takes advantage of an Aβ-degrading enzyme to increase Aβ turnover. It is particularly useful as this enzyme can clip the oligomers. It will be very useful to know whether the treatment reduces pro-NGF and increases NGF ...
COMMENT This will be exciting to watch and follow up. sambak 0 ...
COMMENT The role of the cytoplasmic fragment generated by γ- secretase cleavage in APP function and AD I am glad to see that there is more interest in this "other half." My lab has been interested in CTFγ for a number of years now. Click for image 1 As ...
