Takaomi Saido on Closing in on a Blood Test for Alzheimer’s?

COMMENT This is a well-planned, impressive study that relates brain Aβ amyloidosis with plasma Abeta and related peptide parameters. The methods used, IP-MS, are relatively simple, so there are going to be additional studies that try to confirm the observations ...

Takaomi Saido on There’s No Tomorrow for TOMMORROW

COMMENT The results are not surprising because TOMM40 is not a major risk factor of AD. Takeda has made a simple mistake in R&D management (see You et al., 2017).  saido 0 APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older ...

Takaomi Saido on Aβ Plaques: Breeding Ground for Toxic Tau?

COMMENT Based on pathological chronology and genetic evidence, I and others have postulated that Aβ is like the Mafia boss and tau is the hitman. The question is, how does Aβ amyloidosis induce tauopathy? In a previous study, a team led by Brad Hyman showed that ...

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