Paul Saftig on A Secretase Complex Built for Two

COMMENT This study certainly contains a huge amount of biochemical and microscopy data supporting a close interaction between the γ-secretase complex and α-secretase and between γ- and β-secretases. As the authors point out, several γ-secretase interactome ...

Paul Saftig on LOADed ADAM 10 Mutations Bolster Amyloid Hypothesis

COMMENT The human ADAM10 mutations Q170H and R181G within the prodomain of the protein have been previously found in several late-onset AD families (Kim et al., 2009). To validate the pathogenicity of the mutations, classical transgenic mice expressing wild type ...

Paul Saftig on Endocytosis Pulls α-Secretase From Synapses

COMMENT A disintegrin and metalloproteinase 10 (ADAM10) is apparently one of the most critical membrane-associated proteases in the central nervous system (CNS). Its prominent role in the embryonic and adult CNS has been revealed by a number of studies. Next to ...

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