11 RESULTS
COMMENT This interesting paper of Thomas Willnow and colleagues confirms that SORLA/LR11 has a significant role in the regulation of APP processing, thus giving further support to the hypothesis that reduced SORLA expression could be a risk factor for sporadic AD ...
COMMENT Several papers from the groups of Koo, Rebeck, and Hyman support the existence of a trimeric complex formed by two membrane proteins, the LDL-related receptor LRP and APP, together with the intracellular adaptor protein, Fe65 (1-4). Now, this paper by ...
COMMENT This is an important paper, which reports relevant information to understand the functional role of the Fe65 proteins. The results clearly demonstrate that the knockout of two members of the Fe65 protein family results in a phenotype similar to that ...
COMMENT This paper confirms the possible role of Fe65 in the regulation of transcription. I think that all the results currently available are insufficient to exclude (or minimize) the role of APP (or AICD) in the nuclear functions of Fe65. First, intracellular ...
COMMENT It is quite surprising that, despite a huge number of experiments done and papers published, the molecular events responsible for the Alzheimer's phenotype remain obscure. This article is a stimulating exercise that gives support to an alternative ...
COMMENT It is quite surprising that, despite a huge number of experiments done and papers published, the molecular events responsible for the Alzheimer's phenotype remain obscure. This article is a stimulating exercise that gives support to an alternative ...
COMMENT Very good paper! russot 0 ...
COMMENT The observation of the relocalization of I2PPA2/SET/TAF-1 from the nucleus to the cytoplasm in AD neurons is of particular interest because of the possible role of this phosphatase inhibitor in the hyperphosphorylation of tau. Furthermore, we have ...
COMMENT The results reported in this paper demonstrate that p66Shc is involved in the neuronal death induced in vitro by Aβ. Further studies on this topic could be of help to address the relevance of oxidative stress induced by Aβ in vivo, and its role in AD ...
COMMENT The findings described in the paper of Netzer et Al. demonstrating that STI571/Gleevec inhibits Ab production in vivo are of significant interest at least for two reasons: the drug does not affect Notch processing and it is currently used in humans for ...
COMMENT The observation that AICD and Fe65 are nuclear proteins (Minopoli et al., 2001; Kimberly et al., 2001; Cao & Sudhof, 2001; Gao & Pimplikar, 2001) and the similar proteolytic processing of APP and Notch have suggested the hypothesis that APP and ...
