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Tommaso Russo on FE65 interaction with the ApoE receptor ApoEr2.

COMMENT Several papers from the groups of Koo, Rebeck, and Hyman support the existence of a trimeric complex formed by two membrane proteins, the LDL-related receptor LRP and APP, together with the intracellular adaptor protein, Fe65 (1-4). Now, this paper by ...

Tommaso Russo on Gleevec for Alzheimer's?

COMMENT The findings described in the paper of Netzer et Al. demonstrating that STI571/Gleevec inhibits Ab production in vivo are of significant interest at least for two reasons: the drug does not affect Notch processing and it is currently used in humans for ...

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