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Troy Rohn on Tackling Alzheimer’s from the Outside In

COMMENT The paper by Oddo et al, published in Neuron 2004, reaffirmed my belief that Frank LaFerla and his group at UC Irvine will be (if they are not already) at the forefront when it comes to advancing our knowledge of AD. I also heard Dr. LaFerla's talk ...

Troy Rohn on Cell Death: Time to Push It Out of the Doldrums

COMMENT Yong Shen asks whether I consider caspase-mediated cleavage of MAP or tau a normal physiological process or a pathological process. This is an excellent question. We recently published data indicating a role for caspase-mediated cleavage of tau in ...

Troy Rohn on Cell Death: Time to Push It Out of the Doldrums

COMMENT Yong Shen does an excellent job of summarizing some of the important data supporting an important role for cell death in a number of neurodegenerative diseases. Clearly, there are a myriad of possible scenarios that may lead to neuronal cell death, and ...

Troy Rohn on α-Secretase Returns to Center Stage

COMMENT In this study, the authors provide the first in- vivo demonstration of an effect on plaque formation and neuronal function by stimulating the α-secretase pathway involved in APP processing. Presently, there are two known pathways by which APP is processed ...

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