5 RESULTS
COMMENT This paper opens a new way to fight AD. It breaks the paradigm in the sense that upregulating, but not inhibiting, presenilin leads to decreased Aβ42 levels. mmanotas 0 ...
COMMENT The existence of such a hole was previously envisioned in our article, where we explained the hypothetical role of such a pore. mmanotas 0 Are γ-secretase and its associated Alzheimer's disease γ problems? ...
COMMENT Keeping in mind everything that is currently known about PS1 and its main substrate, APP, this paper by Yu et al. was a pioneer in studying the consequences of PS1 inactivation on cognitive deficit. Despite not being recent, there are still some ideas ...
COMMENT There may be a reversible formation of dimers in the APP molecule, before being cleaved by γ-secretase and the subsequent formation of Aβ dimers, thus preserving the molecule for cleavage by α-secretase. Data provided by this extraordinary article based ...
COMMENT The presenilin hypothesis should be explained taken into account the latest findings from the three-dimensional structure of secretase complex and the monomeric condition. If the water channels were, in fact, two distinct channels through which the same ...
