Hanno Roder on Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice.

COMMENT One does not have to go so far as to postulate a different pathology in mice vs. humans to understand the discrepancy. The Aβ-induced cognitive defects in mice could become apparent because of the tremendous overexpression in mice. In humans, Aβ probably ...

Hanno Roder on Research Brief—Flurizan Fails Final Hurdle, Company Discontinues Drug

COMMENT The failure of Flurizan should not be a surprise. NSAIDs were suspected of protective activity based on epidemiological data. Because of a correlation of "epidemiologically active" compounds with activity in cellular assays measuring Abeta 42/40 ...

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Hanno Roder on Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice.

Hanno Roder on Research Brief—Flurizan Fails Final Hurdle, Company Discontinues Drug

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