64 RESULTS
COMMENT It's interesting that Ilya Bezprozvanny mentions the known interaction of TRP channels with PIP2. Di Pialo and colleagues report that Aβ disrupts PIP2 metabolism, which can be prevented in mice haploinsufficient for synaptonanin1 (1). This follows a ...
COMMENT It's of interest that mRNA levels of the calcineurin inhibitor, DSCR1, are also much higher in AD brain (1). The recent study be Lee and colleagues finds that DSCR1 interacts with Tollip and positively modulates IL-1R signalling (2). Tollip is an ...
COMMENT Nitroglycerin is said to easily cross the blood-brain barrier and enhance cGMP expression (1). Perhaps you'd expect to see a lower incidence of AD in those using the Nitrodur patch. Of further relevance to AD is the study by Brink and colleagues ...
COMMENT I have proposed that Aβ may block HPV16 cell entry due to the fact that it depletes dynamin 1. I refer to my hypothesis, A role for the HPV16E7 oncogene in the pathology of DS and AD. ALS Therapy Development Institute, Feb 17, 2009. emaryreid 0 ...
COMMENT The overexpression DYRK1A and RCAN1, an inhibitor of calcineurin A, are thought to be involved in the neuropathology of Down syndrome. It's of interest that Liang and colleagues report that DYRK1A stabilizes the HPV16E7 oncoprotein (1). HPV16 has ...
COMMENT It's interesting that an androgen receptor coactivator interacts with DR6 and that androgen induces the expression of APP. emaryreid 0 Androgen receptor coregulator ARA267-alpha interacts with death receptor-6 revealed by the yeast two-hybrid. ...
COMMENT It's interesting that TFAM can prevent age-dependent memory impairment and loss of neuronal function when overexpressed in transgenic mice. Telmisartan increases expression of TFAM and MTOC1 and has been found to prevent cognitive decline following ...
COMMENT Jennifer Altman comments on the Sabatini finding that Aβ directly reduces the influx of calcium ions through NMDA receptors. The Takasu study (1) reporting that EphrinB2 activation of EphB in primary cortical neurons potentiates NMDA receptor-dependent ...
COMMENT Sawchenko reports that tau phosphorylation is abrogated in the absence of CRFR1. Bale and colleagues report reduced ACTH in CRFR1-deficient mice; therefore, I find it interesting that Nasman and colleagues report a blunted ACTH response to CRF in AD (1,2) ...
COMMENT Tom Fagan reported in previous research news that enhancing PGC-1α expression may be beneficial in the treatment of Huntington disease. He cites the research by Krainc and colleagues that CREB is displaced from the coactivator's promoter by mutant ...
COMMENT It's of interest that Zhao and colleagues (1) found increased efflux of thiamine pyrophosphate in leukemia cells overexpressing the reduced folate carrier. The possibility of reduced cellular thiamine pyrophosphate in DS due to the overexpression of ...
COMMENT It's interesting that the authors report cell cycle-like mechanisms operating in PD brain tissue. I refer to my comment suggesting a role for reduced PIN1 activity and consequently reduced ability to protect Emi1 from degradation in AD. Emi1 ...
COMMENT I'd like to put forward the hypothesis that Aβ may compete with pleiotrophin (heparin-binding growth associated molecule) for binding to VEGF165. Yang and colleagues (1) report that binding of Aβ to VEGF165 inhibits both Aβ-induced formation of ...
COMMENT Cheryl Wellington and colleagues report that ABCG1 modulates the subcellular distribution and proteolytic processing of β amyloid precursor protein and that ABCG1 mRNA levels are twofold more abundant in Down syndrome brain compared to age- and sex ...
COMMENT The study by Biswas and colleagues supporting the role of miscreant cell cycle proteins in Aβ toxicity is interesting. Dysregulation of the cell cycle would seem to be a significant factor in AD. PIN1, which is downregulated by oxidation in AD neurons and ...
