G. William Rebeck on Even Without Amyloid, ApoE4 Weakens Blood-Brain Barrier, Cognition
COMMENT This work greatly builds the literature of amyloid-independent effects of APOE4 in AD pathogenesis. Using diverse imaging and CSF analyses, Montagne et al. show that blood-brain barrier (BBB) leakage in humans is more pronounced in APOE4 individuals with ...