12 RESULTS
COMMENT In this important study, Lu et al. assessed differential effects of APOE4 and PET-quantified Aβ pathology on visual working memory. In 398 cognitive healthy elderly (69-71 years of age and part of the U.K. 1946 Birth Cohort), carrying E4 predicted better ...
COMMENT This is a tour de force study. Liu et al. compared the effects of APOE3 with the APOE3-Jacksonville variant associated with healthy brain aging and reduced risk for AD and dementia with Lewy bodies (DLB), on aggregation of ApoE, lipidation, and ...
COMMENT This study by Wilmanski et al. provides strong additional support for the idea that alterations in, distinct signatures of, and taxonomic diversity and abundance within the gut microbiome play important roles in physiological versus pathological aging, ...
COMMENT Our findings show that the SARS-CoV-2 viral spike protein S1, which is required for cellular uptake of virus, can enter the mouse brain following intravenous or intranasal administration. This might relate to the fact that people with COVID-19 are often ...
COMMENT In this elegant study, the authors used dynamic-contrast-enhanced magnetic resonance imaging (DCE-MRI) in 245 people to provide evidence that apolipoprotein E4 contributes to BBB breakdown in specific brain regions, specifically the hippocampi and para ...
COMMENT This paper is exciting and remarkable for various reasons. PET imaging showed very high amyloid load, but little tau pathology and glucose metabolism in the healthy range, supporting a greater role of tau than amyloid in cognitive injury in AD. The ...
COMMENT As shown by Bales et al. in 1999, ApoE is critical for amyloid deposition; in APP(V717F) transgenic mice on a murine ApoE knockout background, the amount of Aβ40 and Aβ42 immunoreactive deposits and astrogliosis and microgliosis is markedly reduced. ...
COMMENT The Herz laboratory generated an important novel mouse model (bEKO) that expresses ApoE normally in the periphery and none in the brain. They compared this model to ApoE knockouts (ApoE KO), which show a profound elevation in plasma cholesterol and ...
COMMENT This is a very elegant and important study. The researchers studied 815 participants using a mixed model approach for cross-sectional and longitudinal data to assess the potential effects of ApoE ε4 (ApoE4) on longitudinal decline in memory in the absence ...
COMMENT This is a very elegant study supporting a role for neurogenesis in water maze performance. This study re-emphasizes that the design of the water maze test might modulate the ability to detect this role. For example, in this study the effects of reduced ...
COMMENT This pilot study is important in determining the potential therapeutic effects of testosterone supplementation in healthy elderly men and those with mild AD. This study is very timely in light of accumulating prior evidence. (For a review of the ...
COMMENT In an elegant study, Sopher et al. generated and analyzed transgenic mice that express yeast artificial chromosomes carrying the human androgen receptor (AR) with either 20 (AR20) or 100 (AR100) CAGs. In this model, human AR is expressed between 30 and ...
