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Jacob Raber on Human ApoE Antibody Nips Mouse Amyloid in the Bud

COMMENT As shown by Bales et al. in 1999, ApoE is critical for amyloid deposition; in APP(V717F) transgenic mice on a murine ApoE knockout background, the amount of Aβ40 and Aβ42 immunoreactive deposits and astrogliosis and microgliosis is markedly reduced. ...

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