4 RESULTS
COMMENT This paper presents data indicating that palmitoylation of APP in the early secretory pathway regulates its processing by BACE1. The findings are novel and offer a previously unknown aspect of APP biology that could be targeted for therapeutic purposes. ...
COMMENT Several studies have indicated that both cholesterol and sphingomyelin metabolism can affect the generation of Aβ. In this very elegant paper, Tobias Hartmann’s group has decided to go the opposite way and analyze whether Aβ could affect cholesterol and ...
COMMENT Since the appearance of the first epidemiological and animal studies claiming a connection between cholesterol and Alzheimer disease, at least four different aspects of cholesterol metabolism have been directly linked to AD neuropathology: (i) clustering ...
COMMENT Three recent articles (refs. 1, 2, and 3) have suggested that sphingolipid metabolism may be involved in the pathogenesis of Alzheimer’s disease (AD). The first one, from Xianlin Han and colleagues (1), has identified a ~threefold increase in ceramide ...
