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Luigi Puglielli on Peer Pressure? "Pal" Leads APP Down Amyloid Path

COMMENT This paper presents data indicating that palmitoylation of APP in the early secretory pathway regulates its processing by BACE1. The findings are novel and offer a previously unknown aspect of APP biology that could be targeted for therapeutic purposes. ...

Luigi Puglielli on A Better GRIP on the Aβ-Lipid Connection

COMMENT Several studies have indicated that both cholesterol and sphingomyelin metabolism can affect the generation of Aβ. In this very elegant paper, Tobias Hartmann’s group has decided to go the opposite way and analyze whether Aβ could affect cholesterol and ...

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