7 RESULTS
COMMENT Every Brain is a Genetic Mosaic: Implications for Neurodegeneration Cell division, including the key steps of DNA replication and chromosome segregation, must be extremely precise in order to assure the accurate, complete, and equal replication and ...
COMMENT This is an excellent paper. Well-performed and-analyzed experiments clearly show that peripheral Aβ, derived from an APP/PS transgenic mouse, can be delivered through the circulation by parabiosis to the blood and brain of a recipient wt mouse, where it ...
COMMENT Is a deaf, blind neuron still a neuron? Increasing evidence suggests that synaptic dysfunction may contribute significantly to the learning and memory deficits that characterize Alzheimer’s disease and possibly Down’s syndrome, which always leads to AD ...
COMMENT Some papers are especially admirable for their combination of simplicity and significance. Such is the case of the recent report by Netzer and colleagues who show that a γ-secretase inhibitor restores cognitive function in a mouse model of Down syndrome. ...
COMMENT There is a great need to develop a simple, non-invasive diagnostic test for Alzheimer disease. Many people, ourselves included, have tried to apply the old adage "The eyes…are the wyndowes of the mynde..." (T.Phaer; 1545 paraphrasing of Cicero) ...
COMMENT Alzheimer’s disease is a mosaic form of Down syndrome. The data supporting this conclusion have been building in several laboratories, culminating in the excellent work just published by Iourov and colleagues. The story began with a hypothesis that small ...
COMMENT This paper emphasizes the apparent DNA replication of all chromosomes in neurons in AD patients, rather than also mentioning the aneuploidy for specific chromosomes including chromosome 21 that he reported last summer and which is equally consistent with ...
