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Manuel Portero on Research Brief: Mutant Cells Eat Mutant SOD1

COMMENT This is an excellent paper highlighting the importance of ER stress and related genes in motor neuron survival. The authors are able to uncover a previously ill-defined connection between one of the essential ER signaling arms (IRE/XBP-1) and an essential ...

Manuel Portero on ER Struggles in Motor Neurons That Fall to ALS

COMMENT This paper from Saxena et al. is a very interesting, even outstanding paper. Despite that ER stress has been conceptually linked before to ALS development, the experiments performed here offer a novel view on the chronology of facts before denervation and ...

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