6 RESULTS
COMMENT It has long since been believed that measures of cerebrospinal fluid Aβ concentrations more likely reflect Aβ metabolism in the central nervous system (CNS). Previous studies on plasma Aβ have been contradictory and most groups have reported no change in ...
COMMENT This is a comprehensive study that further shows the complexity of the processing of APP and Aβ. The authors have used several different cell lines and a mouse model to show that the γ-secretase inhibitor (GSI) semagacestat may not act as previously ...
COMMENT This is an interesting article, and we agree with its scientific argument. Bart de Strooper is right about the short half-life of semagacestat, and important aspects such as its rebound effect on CSF Aβ levels. Whether this explains the cognitive ...
COMMENT This is a very comprehensive study where the authors have used various techniques and models to show that a specific endopeptidase (AEP) degrades tau. It has been known for some years that tau is degraded and fragments of tau have previously been detected ...
COMMENT From when we first discovered that the β/α generated fragment Aβ1-15 increased in response to γ-secretase inhibitor (GSI) treatment, we have wondered whether inducing the α-secretase pathway is “good or bad.” Lawrence and colleges clearly show that ...
COMMENT Saito and colleagues have generated knock-in mice that cause overproduction of Aβ43. They show that this isoform of Aβ has a higher propensity to aggregate and is more neurotoxic than Aβ42. The conclusion is that Aβ43 in cerebrospinal fluid potentially ...
