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Erik Portelius on Closing in on a Blood Test for Alzheimer’s?

COMMENT It has long since been believed that measures of cerebrospinal fluid Aβ concentrations more likely reflect Aβ metabolism in the central nervous system (CNS). Previous studies on plasma Aβ have been contradictory and most groups have reported no change in ...

Erik Portelius on Semagacestat, a Pseudo γ-Secretase Inhibitor?

COMMENT This is a comprehensive study that further shows the complexity of the processing of APP and Aβ. The authors have used several different cell lines and a mouse model to show that the γ-secretase inhibitor (GSI) semagacestat may not act as previously ...

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