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Amy Pooler on Connectivity, Not Proximity, Predicts Tau Spread

COMMENT This work elegantly addresses an important question: Does tau spread through synaptically connected brain regions as Alzheimer's disease progresses? By using detailed functional connectivity maps and, importantly, two independent cohorts of ...

Amy Pooler on Antibodies Stop Toxic Tau in Its Extracellular Tracks

COMMENT This paper is really interesting – antibodies directed against tau reduced tau pathology in mice expressing a mutant, aggregating form of human tau. The antibody appears to both prevent the formation of extracellular tau aggregates as well as sequester ...

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