14 RESULTS
COMMENT In my opinion, the big environmental cause of AD is likely to be refined, antioxidant-depleted seed oils, which have now been linked to both cognitive decline (Psaltopoulou et al., 2008) and incident AD (Barberger-Gateau et al., 2007). These oils are ...
COMMENT 1. If unprotected dietary linoleic acid (in refined, Vitamin E-deficient vegetable oils) causes this disease (Kalmijn et al., 1997), then a decades-long history of exposure to frying and salad oils, oily cakes and dips, etc., would be highly relevant to ...
COMMENT I have a scientific question: How can aging be a risk factor for Alzheimer's? Diseases have causes, don't they? 1. Most aging humans don't get AD, and no wild animals, eating natural foods, get it, whatever their age. That includes chimps. ...
COMMENT If a disturbed cell cycle was a primary "cause" of AD, as Webber et al. conjecture, how could this explain the phenomenon of twin discordance, or different AD rates in different populations? If Webber et al. cannot take into account such factors ...
COMMENT Michio Hashimoto has shown significant improvement in cognition in rats given β-amyloid infusions into the cerebral ventricles, when the brain was protected with orally administered omega-3 fatty acids (DHA) (Hashimoto et al.,2005.) In addition to better ...
COMMENT 1. It is scientifically and nutritionally ridiculous to give vitamin E without simultaneously replacing peroxidized long-chain omega-3 and omega-6 polyunsaturated essential fatty acids in critical brain synapses (and in mitochondrial membranes, to prevent ...
COMMENT The real nail in the coffin for any drug whatsoever for the blind empirical treatment of Alzheimer's disease is knowing what causes the disease, which is (quite simply) vacuum steam-deodorized, Vitamin E-depleted polyunsaturated vegetable oils (soya ...
COMMENT I sincerely thank Alzforum for publishing my provocative comment on AD and cholesterol, albeit somewhat sanitized of its original pungency! If my theory about refined oils causing sporadic AD is correct, then "stripped" oil (containing little or ...
COMMENT As Sam Gandy says regarding his research on statin effects in Alzheimer disease: "If it seems like a mess, it is." Hippocrates said, "Every disease has a nature of its own, and each arises from its own natural cause." Why, 2,000 years ...
COMMENT Cortisol, I believe, inhibits BDNF expression or function. Fatty diet (low in Essential Fatty Acids-EFA) causes permanent stress in the offspring—with raised cortisol and homocysteine—when consumed in pregnancy. Fatty adult diet causes mitochondrial ...
COMMENT A fatty diet produces oxidative stress, as seen in diabetics, whose urine contains elevated levels of oxidized DNA base products (8-OHdG)—also seen in cases of breast cancer, which has now been firmly linked to a fatty diet (Bingham et al., 2003). How can ...
COMMENT This curious effect of β-peptide oligomers, in first enhancing, then impairing cognition in rats, may have an explanation, as follows: Such oligomers are toxic in Alzheimer's disease because they cause synaptic lipid peroxidation, especially in brain ...
COMMENT What really stumps scientists is scientific method, which means that to find the cause of Sporadic Alzheimer's, you need to go back to Isaac Newton or Charles Darwin, who used exclusively inductive reasoning. Late-onset AD is simply not genetic, ...
COMMENT Any glutamate excess in Alzheimer's may be of glial origin. Aldehydic products of lipid peroxidation apparently inactivate glial glutamate uptake transporters. The correct approach to the problem is at a primary level, by correcting the lipid ...
