5 RESULTS
COMMENT This manuscript reinforces the notion that APP metabolites, including Aβ, participate in pre-and postsynaptic homeostatic mechanisms that regulate synaptic activity (for review, see Palop and Mucke, 2016) and identifies secreted APP as a key element ...
COMMENT To What Extent Do APP Knock-ins Call Overexpression Models of AD into Question? There are many reasons to question the claim that all phenotypes of hAPP transgenic mouse models that are not found in APP-KI mice are artifacts. Most importantly, this ...
COMMENT The paper by Born et al. describes an impressive body of work. We congratulate the authors on their study, which conclusively demonstrates that network hypersynchrony in APP/TTA transgenic mice is (1) reversible, (2) closely associated with behavioral ...
COMMENT Cortical and hippocampal hyperactivity of neuronal networks are early events in AD pathogenesis and are associated with early amyloid deposition in non-demented humans with and without mild cognitive impairment (MCI) (Sperling et al., 2009; Putcha et al., ...
COMMENT Comment by Jorge J. Palop and Lennart Mucke We completely agree with Dr. Ashford in that the specific connection between Aβ and tau revealed by this and our previous study (Roberson et al., 2007) deserves to be explored further. However, we believe that ...
