10 RESULTS
COMMENT This is an interesting paper describing the development of a new microglia PET tracer that binds to the CSF1 receptor. Several experimental models have been tested in vitro and in vivo in the paper showing a good binding that can be blocked. Many ...
COMMENT We are in an exciting period, with new data regarding both old and new PET tau tracers. The picture, however, is probably very complex. It is quite possible that a single PET tau tracer will be insufficient to capture human tauopathies, because tau exists ...
COMMENT More and more, it is realized that the structural changes (volume losses) in the brain leading to Alzheimer's disease are preceded by more subtle but significant brain changes. Here, the authors show that, since stable MCI (sMCI) patients showed ...
COMMENT This paper focuses on a very important issue, namely, whether subjective cognition might be a very early sign for existing brain pathology leading to Alzheimer's disease. Since the subject population was quite old (above 70) and very highly educated, ...
COMMENT This is a study of 105 normal controls, 175 MCI, and 90 AD patients followed for on to two years. CSF biomarker and brain atrophy were used as predictive parameters for clinical changes in AD. Surprisingly the authors reported that MCI patients with CSF ...
COMMENT In this study, Liu et al. demonstrate the co-assembly of α7 nicotinic receptors and β2 subunits. The increasing knowledge of the functional role of α7 nicotinic receptors in brain is fascinating. It appears more relevant that the α7 nicotinic receptors ...
COMMENT It has been six years now since the first Alzheimer patient was scanned with PIB in Sweden (Klunk et al., 2004). It was quite obvious already from the first PIB scans that there was a robust difference in PIB retention in cortical brain regions of mild AD ...
COMMENT This is the first time an amyloid imaging ligand such as PIB has been used in the evaluation of a drug treatment study in mild AD patients. This is a double-blind study. It shows that in phenserine-treated AD patients, there is in some patients a ...
COMMENT In this study, the authors have used a somewhat unusual approach to recruit patients to take part in PET studies of Alzheimer disease (AD) and mild cognitive impairment (MCI). They have made advertisements about the study, including media coverage. From ...
COMMENT The number of patients with mild cognitive impairment (MCI) is increasing and many of them are referred to memory clinics. The cognitive decline in MCI is greater than in normal aging, but the clinical characteristics are heterogeneous and some people may ...
