11 RESULTS
COMMENT We agree with Xiongwei Zhu and Wenzhang Wang on significant evidence supporting a critical role of mitochondrial dysfunction in Alzheimer's disease. We have pursued this premise to conduct IRB-approved placebo controlled clinical trials in human LOAD ...
COMMENT Molecular Magneto is a very interesting and exciting technique for laboratory research on calcium channels, GABAnergic neurons, and gene control. None of this is surprising to those who have been studying magnetic fields in the laboratory or clinically. ...
COMMENT This report of extensive CTE in a young adult with repeated concussions is a cautionary tale. PET scanning of taupathy probably will not be adopted widely to detect CTE in adolescent athletes. However, diffusion tensor imaging of sports-related concussion ...
COMMENT The researchers are to be commended for realizing the emerging role of pathogens in Alzheimer's disease. We submitted an abstract on this topic for the Society for Neuroscience Annual Meeting in 2012 based on the work of Alan MacDonald, Nias Mattsson ...
COMMENT The clinical study of using IVIG in MCI as reported above by Kile is encouraging to those supporters of the "emerging role of pathogens in Alzheimer’s disease." Hopefully, the larger clinical trial of IVIG, as mentioned by Norman Relkin in 390 ...
COMMENT The science of concussion and chronic traumatic encephalopathy (CTE) is still emerging. Here are some findings from the literature. Christopher Giza at the University of California, Los Angeles, has published on the neurometabolic cascade of concussion. ...
COMMENT A most interesting animal model of AD, not only with the Aβ peptide, intracellular and extracellular accumulations of tau protein, and ubiquitin, but also demonstrating strong astrocytic responses and acetylcholinesterase (AChE)-rich pyramidal neurons ...
COMMENT BACE1 inhibition is an important potential theurapeutic arm of the β amyloid clearance phenomenon in Alzheimer's which needs to be realized clinically. However, another BACE1 inhibitor, minocycline, which is also neuroprotective and is already an ...
COMMENT Magnetic induction of current, if done transcranially, is anti-inflammatory. We have studied this for six years in both human and animal models of a number of diseases. The implanted coils are interesting and may prove to be a more successful application ...
COMMENT A very important B study, but one lacking a methyl donor with the B6, folate, and B12. Unfortunately, the majority of therapeutic trials of the B vitamin ignore methyltetrahydrofolate reductase deficiency as a subgroup of Alzheimer's, which would be ...
COMMENT As a member of the SfN, we submitted a mini-symposium for the 2006 conference on the possible pathogenesis of Alzheimer's as a consequence of latent infectious agents, and of course were turned down. I was familiar with Alan MacDonald's, Judith ...
