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Rachael Neve on Presenilin Loss of Function—Plan B for AD?

COMMENT Thank you to Jie Shen and Raymond Kelleher for kicking off this discussion with their very provocative hypothesis published in PNAS. There have been many interesting comments posted—but one thing that strikes me is the (often unspoken) assumption made in ...

Rachael Neve on APP Double Dose Causes Early Onset AD

COMMENT Obviously, the excitement of the paper derives from the fact that simple duplication of the APP gene can cause AD. Scientists had always assumed that it is the extra copy of APP that is responsible for the Alzheimer disease pathology that develops in ...

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