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COMMENT The comments above raise important issues related to an understudied but common disease(s). I first offer individual responses, then some overarching points. I agree with Dr. Boxer that therapeutics for one subtype of TDP-43 proteinopathy may work for ...
COMMENT TMEM106B has a strong association with brain pathology and was discovered as a risk allele in diseases on the ALS/FTLD spectrum. But indeed, the main impact of TDP-43 proteinopathy on public health is on LATE, which is >100-fold more common than ALS ...
COMMENT Hi, a few quick comments... 1. The consensus working group report on LATE was that—a distillation of what an international, multidisciplinary group could agree on. 2. The goal was not to produce a trendy new term. For me personally, a key goal was to have ...
COMMENT Zhao and colleagues studied neurocognitive outcomes over ~12 years for 175 persons stratified by baseline PiB-PET (Aβ) status and structural MRI (operationalized by hippocampal volume, HV). The research participants were a subgroup of the Ginkgo ...
COMMENT Duyckaerts et al. raise a number of questions. A comprehensive commentary on this paper from a large group of coauthors, including myself, is currently under review at Acta Neuropathologica. For now, speaking only for myself, and leaving aside ...
COMMENT This is an interesting conversation among highly respected scientists. I'll just add one additional perspective. Clinico-neuropathological correlation data, although complex, are compatible with the hypothesis that "something" (genetics ...
COMMENT I have much respect for Dr. Herrup and for his scholarly review article. I agree that dementia comes from many different diseases, and aging no doubt plays a role in some dementia subtypes. Focusing on non-AD processes linked to aging is laudable and ...
COMMENT The paper by Elisa Vilardo et al. on miR-101 regulating APP (Francesca Ruberti, corresponding author) looks like a very nice addition to the growing literature indicating that genes related to neurodegeneration in humans are regulated in part through ...
COMMENT These papers contain nice work. Since the work comes “in stereo” in a great journal, it seems all the more significant. It's rare but not unprecedented to see such similar cutting-edge research from two excellent labs. I think these data are ...
COMMENT Jongpil Kim and colleagues from Asa Abeliovich's group have produced a very important work that indicates a particular microRNA (miRNA) may play a critical role in Parkinson disease. This study is important for a number of reasons. First, it ...
COMMENT The thrust of this paper is that the noncoding RNA BC1 is responsible for regulating D2-mediated synaptic transmission. Perhaps the greatest strength of the study is the robust neurophysiology and pharmacology with tight controls. That data set shows, ...
COMMENT Anne Schaefer et al. have produced an important study about miRNAs in the mouse cerebellum. Their data suggest that miRNA function is critical for mammalian neuronal survival. The authors conclude that since dicer downregulation causes neuronal cell death ...
COMMENT A high-quality study from a well-respected group of clinicians and pathologists. ptnelson 0 ...
COMMENT I think that the evidence of disruption/change of cell cycle protein expression in Alzheimers disease is very intriguing. ptnelson 0 ...
COMMENT An increasingly compelling model of AD pathology is IBM. ptnelson 0 ...
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