68 RESULTS
COMMENT The cholinergic hypothesis of AD has been a staple of the field for many years. This hypothesis was the result of the classic studies showing a loss of cholinergic neurons in the basal forebrain and a decrease of cortical cholinergic activity in AD (see ...
COMMENT What is most striking in this work is the observation that Aβ initiates axonal synthesis, a process that has been discussed in other systems. Aβ induces the axonal synthesis of the transcription factor ATF4. The authors use a microfluidic chamber to ...
COMMENT This most interesting paper presents a well-designed set of experiments, which provide evidence that two novel high-affinity RAGE-specific blockers inhibit Aβ40- and Aβ42-induced cellular stress in vivo and in vitro. In particular, FPS-ZM1 significantly ...
COMMENT Sperling and colleagues suggest that brain amyloid deposition drives the clinical sequelae associated with AD, and that anti-amyloid-based therapies continue to be the most promising treatment for the disease. They argue that a reason for the failure of ...
COMMENT These types of press releases and hyped reviews only give false hope to the public. The AD community should be more aware of the impact that such company-driven statements have on the families of those suffering from the disease. emufson 0 ...
COMMENT This is an interesting and well-presented study, but as with many studies of Aβ toxicity, the dose used is extremely high and may not recapitulate what occurs in the human brain in patients with AD. Extrapolation from cell culture to the human disease is ...
COMMENT The findings of Alix de Calignon and colleagues are interesting and support several studies using human AD tissue that show caspase plays a pivotal role in tangle formation. However, given the recent indications that AD has a preclinical phase of between ...
COMMENT This may be a naive question, but if amyloid deposition in the brain is a critical factor in AD-related behavioral sequelae, why is it so difficult to induce a behavioral modification of statistical relevance following Aβ vaccination, since reports show a ...
COMMENT This interesting concept could begin to explain the widespread amyloid response in AD and in prodromal AD. It may also begin to shed some light as to why Aß vaccination has not been a successful treatment approach. emufson 0 ...
COMMENT The neurotrophin nerve growth factor (NGF) and its high-affinity receptor TrkA play a major role in the survival of basal forebrain cholinergic neurons, which are selectively vulnerable during the progression of AD (Counts et al., 2004). Degeneration of ...
COMMENT The work by Klunk and coworkers (2007) demonstrates how incomplete our understanding is of the early neuropathobiological events that occur in both FAD as well as sporadic AD. Interestingly, we recently demonstrated an age-related increase in striatal ...
COMMENT I was a speaker at the AD/PD meeting in Salzburg. My congratulations go out to the organizers of the congress for an excellent meeting, which provided outstanding sessions and plenty of time to discuss science with colleagues. In the session in which I ...
COMMENT The articles by Dorsey and colleagues and Mobley's group (see Salehi et al., 2006) are particularly relevant to recent findings that our group has generated using human autopsy material to investigate the neurobiological mechanisms underlying ...
COMMENT The search for a biomarker that distinguishes AD from other neurological dementias is a fertile research area for both clinical, basic, and biotech investigators. In this article, findings are presented demonstrating the ability of gene array technology ...
COMMENT Rosch and colleagues in the May 17 issue of PNAS provide intriguing new data implicating p75NTR in activity-dependent synaptic plasticity. The authors use two strains of p75NTR mutants (p75NTRexonIV-/- and p75NTRexonII-/-) to investigate the emerging ...
