13 RESULTS
COMMENT We applaud this careful genetic and phenotypic analysis of the rTg4510 model and encourage similarly comprehensive investigations of other widely used mouse lines. Along this line, we recently demonstrated that in the hAPP-J20 mouse model, the transgene ...
COMMENT This instructive report by Lam et al. nicely demonstrates in Alzheimer’s disease (AD) patients what is well recognized in the epilepsy field, but widely underappreciated in AD research: the absence of obvious seizure activity by clinical observation and ...
COMMENT As recently reviewed in some depth (Palop and Mucke, 2016) and prospectively demonstrated in the clinic (Vossel et al., 2016), there clearly is an important link between Alzheimer’s disease and epilepsy, which may involve a vicious cycle between aberrant ...
COMMENT To What Extent Do APP Knock-ins Call Overexpression Models of AD into Question? There are many reasons to question the claim that all phenotypes of hAPP transgenic mouse models that are not found in APP-KI mice are artifacts. Most importantly, this ...
COMMENT The paper by Yetman et al. provides a valuable resource for investigators planning experiments with this neuropsin-tTA driver line, and the availability of this data in an open-access resource should be lauded. While bringing important attention to the ...
COMMENT The paper by Born et al. describes an impressive body of work. We congratulate the authors on their study, which conclusively demonstrates that network hypersynchrony in APP/TTA transgenic mice is (1) reversible, (2) closely associated with behavioral ...
COMMENT I fully understand and share Dr. Strittmatter’s eagerness to resolve the controversy surrounding his original findings. As pointed out in our paper, the different effects of PrPC ablation on Aβ-induced functional deficits observed by different ...
COMMENT Reply to comment by Nikolaos K. Robakis I much appreciate Nick’s comments, and fully agree that all experimental models must be put into proper perspective. In regards to our paper, this perspective should include the fact that Mother Nature herself has ...
COMMENT By demonstrating a selective vulnerability of hilar interneurons to intracellularly generated neurotoxic ApoE4 fragments, Andrews-Zwilling et al. identified an interesting new mechanism through which ApoE4 could contribute to neural network dysfunction in ...
COMMENT I am very enthusiastic about the paper by Ittner et al. for several reasons. First, it confirms the highly protective effects of tau reduction we observed in hAPP-J20 mice (Roberson et al., 2007 and Palop et al., 2007) in another APP transgenic line with ...
COMMENT The results are very interesting and relate closely to findings we obtained in hAPP transgenic mice and humans with AD (1). In our study, we documented a depletion of reelin-positive pyramidal neurons in layer II of the entorhinal cortex in both the ...
COMMENT Comment by Rene Sanchez-Mejia and Lennart Mucke We thank Tom Fagan, Tobias Hartmann, James Lee, and Grace Sun for their kind words about our paper. A few comments may help clarify some of the issues raised. The excellent work by Roberto Malinow (Hsieh et ...
COMMENT I appreciate Drs. Iijima and Iijima-Ando’s comments on our paper and would like to address a couple of points they raised. 1. “Why does the Arctic mutation cause FAD, if Aβ-Arctic is less toxic than wild-type Aβ (Aβ-Wt)?” Our study demonstrates that high ...
