11 RESULTS
COMMENT This elegantly designed study sounds like a mini- “thunderclap” or “revolution” for the field of blood-brain barrier (BBB) research. It is accepted that the BBB becomes more permeable as we age (Montagne et al., 2015). However, this article suggests that ...
COMMENT Joel Blanchard and Li-Huei Tsai have developed an interesting in vitro BBB model made of human induced pluripotent stem cells (iPSCs) differentiated into endothelial cells, pericytes, and astrocytes, that they named iBBB. First, they found that iPSC ...
COMMENT This is a noteworthy study by the Daneman lab comparing the transcriptional profiles of mouse blood-brain barrier (BBB) endothelial cells (ECs) with those in other organs of the body (i.e., heart, lung, kidney, and liver) using RNA-Seq method and an ...
COMMENT This article by Cakir et al. provides what we believe to be a very important method for modeling a human brain in a dish with a functional vascular-like network. In this paper, Dr. Park and his colleagues demonstrated that it is possible to obtain ...
COMMENT Akassoglou’s lab has published a very elegant study demonstrating that blood-derived fibrinogen that leaks out into the brain is synaptotoxic and leads to cognitive impairment independently of amyloid pathology. The authors also found that fibrin(ogen) at ...
COMMENT The concept of “VCAM-1 opening the door to aging” is very interesting and fascinating. Aging has been associated with a low‐grade inflammatory status of the immune system, commonly called “inflammaging,” a contraction of inflammation and aging (Franceschi ...
COMMENT In 1787, anatomist Paolo Mascagni published an atlas of all lymphatic vessels in the human body, which included the brain, where he described the presence of lymphatics in the cerebral dura mater (Mascagni, 1787, Vasorum Lymphaticorum Corporis Humani ...
COMMENT There is increasing evidence that enlarged perivascular spaces (PVSs) are associated with cerebrovascular dysfunction, as well as with cognitive decline and dementia. Using combined T2-weighted fluid attenuated inversion recovery (FLAIR) and T2*-weighted ...
COMMENT Machuca-Parra and colleagues present an interesting study showing that Notch3 signaling is linked to vascular smooth muscle cells (VSMCs) coverage in retinal vessels and demonstrate that restoring Notch3 signaling via genetic rescue and using a Notch3 ...
COMMENT Glial cells constitute more than 50 percent of the cells in the human brain. Astrocytes, which make up the largest glial population, are crucial to the regulation of synaptic connectivity and plasticity, brain tissue repair, formation of the blood-brain ...
COMMENT Growing evidence suggests that maintaining a physically active lifestyle may be particularly beneficial in reducing the risk for dementia and Alzheimer's disease. In this paper, Soto et al. convincingly show that exercise in aging mice preserves the ...
