11 RESULTS
COMMENT The Holtzman group's anti-ApoE antibody (HAE-4) recognizes human ApoE4 and ApoE3. This antibody binds specifically to non-lipidated human ApoE4 and ApoE3 and, when delivered to ApoE4-expressing mice, reduces Aβ deposition (Liao et al., 2018). These ...
COMMENT While much of the genetic study of AD focuses on risk factors and causes of the disease, it is at least as important to identify corresponding protective factors. This study takes this approach by focusing on factors that protect/delay onset of disease by ...
COMMENT This study, from the Holtzman group, shows that intracerebroventricular and intraperitoneal administration of an anti-human ApoE antibody, HAE-4, which binds similarly to ApoE3 and ApoE4, reduces Aβ plaques and Aβ accumulation in brains of APPPS1/ApoE4 ...
COMMENT I first met Allen shortly after his seminal ApoE4 work was published, when he visited Tel Aviv University. Sitting on the beach, he expressed his opinion on my AD work at the time, stating that it was off the main focus of the field (he probably said it ...
COMMENT The finding outlined in this paper that long-chain omega-3 fatty acids are protective in human ApoE4 carriers extends and validates our previous findings with targeted replacement mice that express either human ApoE4 or human ApoE3, which revealed that ...
COMMENT The pivotal publication from the Landreth group that the RXR agonist and anti-cancer drug bexarotene lowers the levels of Aβ in vivo and that this is associated with increased levels of ApoE (Cramer et al., 2012) paved the way for a new therapeutic ...
COMMENT This recent paper by Mak et al., describes the effects of ApoE deficiency in a 40-year-old human patient. The results revealed that, despite complete absence of ApoE, the patient had normal vision, exhibited normal cognitive neurological and retinal ...
COMMENT Since the introduction of a novel approach, such as the use of the RXR agonist bexarotene to counteract AD pathology, often brings controversy, it is important to identify consensus observations that ensue. A key finding from the Landreth group (Cramer et ...
COMMENT This study reports that ApoE4 is associated in neonates with a decrease in the volume of distinct brain areas affected in AD, such as the hippocampus, and with an increase, which is presumably compensatory, in the volume of other brain areas such as the ...
COMMENT Reply to Thomas Ohm: We agree with Dr. Ohm's comments regarding the conceptual difficulties of comparing the effects of an endogenous molecule to that of an analogous transgenic molecule from another species. However, since the levels of expression ...
COMMENT The increasing number of isoform-specific pathological effects of ApoE4, which were so effectively reviewed by Gabrielle Strobel, suggest that ApoE4 may exert its pathological effects by several different mechanisms whose relative importance are context ...
