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COMMENT Thanks for reaching out regarding Lilly’s perspective on this paper. As is always the case with developing innovative medicines, we spend a significant amount of time trying to better understand potential organ effects related to a specific target. In the ...
COMMENT LY2811376 represents a breakthrough in targeting BACE1, the protease that initiates the amyloid cascade. After 10 years of research, many in the field were beginning to question whether this critical protease could be targeted with a small-molecule ...
COMMENT This is an interesting paper examining the potential role of the endocannabinoid system in affording protection against excitotoxic seizures elicited by kainic acid. Clearly, mice lacking CB-1 receptors exhibit more severe behavioral seizures in response ...
COMMENT In developing small molecule therapeutics, drug hunters targeting neurodegenerative diseases have to overcome an added barrier, both figuratively and literally. In general, the experimental therapeutic must pass the blood-brain-barrier (BBB) in order to ...
