12 RESULTS
COMMENT The new findings of Villeda et al. are remarkable and thought-provoking, as they suggest the possibility that transfusion of blood/plasma from young humans can restore cognitive function in patients with mild cognitive impairment or Alzheimer’s disease. ...
COMMENT A Hypothalamus-Centric Inflammation-Mediated View of Aging. What About Energy Metabolism? Zhang et al. (1) report three remarkable findings that transcend the fields of aging, neuroscience, and immunology. First, by selectively manipulating the activation ...
COMMENT There has been a flurry of articles published within the past few years in which relatively shorter telomere length in lymphocytes has been associated with aging and numerous chronic diseases. A common factor in these conditions is that there is elevated ...
COMMENT Nicholson and Ferreira’s new findings provide an important advance in our understanding of why high cholesterol levels may increase the vulnerability of neurons to dysfunction and death in Alzheimer disease. Previous studies in my laboratory and other ...
COMMENT Matsuno et al. identify the gene responsible for the impaired long-term memory (LTM) phenotype in the Drosophila Rus mutant as an allele of klingon which encodes a protein that functions in cell adhesion. Levels of klingon are reduced in Rus mutants, and ...
COMMENT The findings of Schriner et al. provide an important advance in understanding the contributions of metabolism of reactive oxygen species to aging and lifespan in mammals. Their data strongly suggest that production of hydrogen peroxide in mitochondria is ...
COMMENT Because the production of new neurons from stem cells occurs in the adult brain and may decline during normal aging (1), and in light of emerging evidence that neurogenesis may play an important role in learning and memory (2), it is important to ...
COMMENT The discoveries that neurons that mediate birdsong in canaries are replaced by new neurons produced from stem cells, and that this turnover of the neurons is regulated by testosterone in a seasonal manner, have provided important insight into the control ...
COMMENT The results of the trial of Coenzyme Q10 in Parkinson's patients are very encouraging and provide a rationale for longer-term therapy. There is a solid basis for believing that CoQ10 may also benefit patients with Alzheimer's disease, ...
COMMENT The quantitative analyses of volumes of different brain structures in an APP mutant mouse line by Redwine et al. provide valuable new information concerning the possible relationships between altered APP processing, amyloid deposition, and cellular damage ...
COMMENT The analyses of mice with adipose cell-specific knockout of the insulin receptor (FIRKO mice) by Bluher et al. provide at least three major advances in our understanding the mechanisms whereby insulin signaling and energy metabolism regulate life span. ...
COMMENT This is potentially one of the most important findings in the Parkinson's disease field in recent years. What is particularly important is that the DJ-1 gene apparently encodes a protein involved in cellular resistance to oxidative stress, and that ...
