Rudolf Martini on Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system.
COMMENT This work deals with the role of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) in nerve lesions and toxic neuropathies in mice. The enzyme generates the well-known amyloid-β peptide, which is a pathogenetically relevant component of plaques ...