5 RESULTS
COMMENT I think this is a very elegant study that reveals the fundamental role of nicastrin in neuronal integrity and memory in adult mice. This work also confirms in vivo, in the adult brain, that nicastrin is essential for the stabilization and activity of the ...
COMMENT Converging evidence strongly supports the notion that intracellular calcium is a key player in the regulation of APP metabolism. The different studies that have investigated this mechanism have, however, generated puzzling results, making it difficult to ...
COMMENT This is a very interesting paper that strengthens further the notion that natural grape-derived polyphenols may exert potent anti-amyloidogenic effects in vivo. Moderate consumption of red wine is believed to reduce the incidence of dementia and Alzheimer ...
COMMENT A consensus about the exact molecular mechanism by which PS1 pathogenic mutations affect APP processing in the diseased human brain, or even in cell culture or animal models, seems difficult to reach. This lack of consensus is nicely highlighted in the ...
COMMENT It is difficult to know whether the anti-amyloid effect of the mentioned natural compounds (i.e., resveratrol or EGCG) observed in cell culture systems or even in mouse models may explain or support the beneficial effect of specific diets. This effect may ...
