7 RESULTS
COMMENT "Tau factor" was initially described by Marc Kirschner and colleagues as a protein promoting the assembly of microtubules (MT) in neurons (Weingarten et al., 1975). Within the same year Joe Bryan and colleagues showed that tau also interacts ...
COMMENT This paper by Fitzpatrick et al. is a seminal accomplishment in two fields—structural biology and neurodegeneration research, both achieved at the MRC LMB in Cambridge, U.K. For structural biology, it is an example of the recent revolution in high ...
COMMENT The post-translation modifications (PTMs) of tau have long been proposed to play an important role in tau aggregation and tau-mediated neurodegeneration. However, the overall PTMs of tau under physiological conditions are not well elucidated. By using an ...
COMMENT We did not study CSF-tau in our lab, but our thinking was always primed by the early findings of Gail Johnson, Doug Galasko, and colleagues that CSF tau consists essentially of N-terminal fragments in the range of 25 kD (Johnson et al., 1997). In the new ...
COMMENT This work is fantastic. It explains why antibody therapy might work for tau pathology, which was a matter of debate in the past. Einar Sigurdsson's group at NYU had shown that antibodies against tau can somehow reduce the pathology, but it was not ...
COMMENT I was impressed by Kishore Kuchibhotla's presentation. The work combines clever technology with significant results. There has been a longstanding debate on whether tangle-bearing neurons are functional or withering away because of the toxic tau ...
COMMENT The commentary by Claude Wischik contains a review of some key discoveries in the study of the structure of paired helical fragments (PHFs) of tau, many by him and his collaborators, including the inhibitory effects of methylene blue on tau aggregation. ...
