12 RESULTS
COMMENT The Ikezu lab has published a series of pioneering papers on the role of exosomes/extracellular vesicles (EVs) in neurodegeneration, notably the role of exosomes in the spreading of tau pathology via microglia (Asai et al., 2015). The distinction between ...
COMMENT This paper represents a major advance in the understanding of molecular changes in neuronal tau protein during the progression of Alzheimer‘s disease. This was made possible in large part by advances in mass spectroscopy methods, making use of calibration ...
COMMENT We were shocked by the news of the untimely death of Peter Davies, and we second all the thoughtful and warm remarks made by colleagues about the remarkable person he was. We met Peter on numerous occasions at SfN or Alzheimer meetings. In the late 1980s ...
COMMENT In our paper, now in press at Mol. Neurodegeneration, we argue that the repeat domain of Tau, when coupled to GFP, cannot form amyloid-like Tau filaments because of steric hindrance. GFP is too big to fit onto the tight cross-β structure of an amyloid ...
COMMENT In the early days of research on the role of Tau protein in AD, Brad Hyman and colleagues showed that the distribution of neurofibrillary tangles in the brain was a better predictor of the progression of AD than senile plaques (Arriagada et al., 1992), ...
COMMENT "Tau factor" was initially described by Marc Kirschner and colleagues as a protein promoting the assembly of microtubules (MT) in neurons (Weingarten et al., 1975). Within the same year Joe Bryan and colleagues showed that tau also interacts ...
COMMENT This paper by Fitzpatrick et al. is a seminal accomplishment in two fields—structural biology and neurodegeneration research, both achieved at the MRC LMB in Cambridge, U.K. For structural biology, it is an example of the recent revolution in high ...
COMMENT The post-translation modifications (PTMs) of tau have long been proposed to play an important role in tau aggregation and tau-mediated neurodegeneration. However, the overall PTMs of tau under physiological conditions are not well elucidated. By using an ...
COMMENT We did not study CSF-tau in our lab, but our thinking was always primed by the early findings of Gail Johnson, Doug Galasko, and colleagues that CSF tau consists essentially of N-terminal fragments in the range of 25 kD (Johnson et al., 1997). In the new ...
COMMENT This work is fantastic. It explains why antibody therapy might work for tau pathology, which was a matter of debate in the past. Einar Sigurdsson's group at NYU had shown that antibodies against tau can somehow reduce the pathology, but it was not ...
COMMENT I was impressed by Kishore Kuchibhotla's presentation. The work combines clever technology with significant results. There has been a longstanding debate on whether tangle-bearing neurons are functional or withering away because of the toxic tau ...
COMMENT The commentary by Claude Wischik contains a review of some key discoveries in the study of the structure of paired helical fragments (PHFs) of tau, many by him and his collaborators, including the inhibitory effects of methylene blue on tau aggregation. ...
