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Kun Ping Lu on Pin1 mediates Aβ42 -induced dendritic spine loss.

COMMENT This paper by the Malter group elegantly demonstrates a signaling cascade initiated by soluble Aβ42 that leads to calcineurin activation and Pin1 inhibition, thereby negatively affecting dendritic spine health. These findings are interesting and ...

Kun Ping Lu on Longevity Tied to Insulin Action in Brain

COMMENT Comment by Kazuhiro Nakamura and Kun Ping Lu Aging, Cancer, and Neurodegeneration Matheu et al. (1) have made the important discovery that overexpression of both Arf and p53 under normal regulation can confer cancer resistance, reduce aging-associated ...

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