3 RESULTS
COMMENT In this elegant paper, the authors demonstrated for the first time that the P301L/S mutation in tau attenuated the activity-dependent increase in blood flow to the brain. It is widely believed that cerebrovascular dysfunction in Alzheimer’s disease (AD) ...
COMMENT The abnormal acetylation of tau lysine 280 (K280) has recently received great attention in AD research. It has been proposed to be a novel pathological signature of AD (see Cohen et al., 2011). The present paper has characterized the effect of deleting ...
COMMENT The paper from Lennart Mucke’s group demonstrates that Aβ-induced synaptic dysfunction depends upon cellular alterations in tau proteins. In contrast, our paper (Hoover et al., 2010) mainly focuses on how cellular alterations in tau proteins themselves ...
