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Malcolm Leissring on Novel Aβ Protease Found in Mitochondria

COMMENT Our group recently discovered that insulin-degrading enzyme (IDE) itself is targeted to mitochondria, as well (Leissring et al., 2004). This mitochondrial isoform of IDE is generated by alternative translation initiation at an upstream codon. At the time ...

Malcolm Leissring on Metalloproteases—A Shining Challenge to Aβ

COMMENT Back in the good old days, when AD research was hyperfocused on Aβ production and aggregation, defining the mechanism of a given treatment that lowers net Aβ production was a relatively simple matter: Just check relative levels of Aβ precursor protein ...

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