Gary Landreth on In Alzheimer’s, More TREM2 Is Good for You

COMMENT The roles of TREM2 in AD pathogenesis have commanded substantial attention following from the recognition that TREM2 variants are associated with dramatically elevated AD risk. Previous work from this group reported that soluble forms of TREM2 were found ...

Gary Landreth on Human ApoE Antibody Nips Mouse Amyloid in the Bud

COMMENT Liao et al. have reported that antibodies directed at human ApoE isoforms can reduce amyloid plaque burden in a mouse model of AD expressing human ApoE4. This study, like its predecessors from the Holtzman lab, derives from the recognition that plaques in ...

Gary Landreth on Wiping Out Microglia Prevents Neuritic Plaques

COMMENT The authors present an intriguing study that highlights the interplay between microglia and neurons in the progression of amyloid pathology in a mouse model of Alzheimer’s disease. Although others have demonstrated that early intervention with CSF1R ...

Gary Landreth on Does Soluble TREM2 Rile Up Microglia?

COMMENT Zhong et al. report that soluble forms of TREM2 are able to elicit a robust proinflammatory response and promote survival in primary microglia. These findings provide a completely novel take on the biological roles of soluble TREM2. Previous work has ...

Gary Landreth on PTEN Makes Aβ Depressingly Toxic

COMMENT This is an interesting and thorough study, whose experimental outcomes are pretty clear. One question one could ask is why chronic treatment with the PTEN inhibitor is necessary to improve the behavioral outcomes. There is no change in pAKT in the chronic ...

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