10 RESULTS
COMMENT In this paper, Chia et al. described the analysis of an impressive volume of whole-genome-sequencing (WGS) data with the main objective to characterize genetic determinants of Lewy body dementia. They report five genome-wide significant signals, three ...
COMMENT This work has several objectives: (i) to establish a systematic mapping of transposase-accessible chromatin (ATAC) regions in seven brain regions from 39 healthy individuals; (ii) from some of the samples used in the previous bulk assay, to perform a ...
COMMENT The Nott et al. paper is of particular interest for those of us who try to decipher how genes can be potentially regulated in different brain cell types through common and specific enhancers. In particular, the authors beautifully demonstrated that an ...
COMMENT This work is based on an impressive number of sequencing data generated from Alzheimer’s patients and controls, and primarily analyzes loss-of-function (LOF) variants. The major result obtained in this analysis mainly replicates the association of rare ...
COMMENT It is well accepted that knowledge of the genetic determinants of AD should improve our understanding of the fundamental disease processes. However, when identified, it is often difficult to understand how genetic variants mechanistically contribute to AD ...
COMMENT The search for blood biomarkers is obviously of high interest for Alzheimer’s disease diagnosis, and it is always disappointing to see promising results not being replicated. However, it is not a big surprise, and I encourage people working in this field ...
COMMENT The paper by Yu et al. is a complementary study of a very recent work published by the same team in Nature Neuroscience (De Jager et al., 2014). In the first study, the authors studied the epigenome in the brains of 704 autopsied samples from two very ...
COMMENT In a report published in the American Journal of Human Genetics, Shulman and collaborators report a two-stage strategy to characterize new genetic determinants of Alzheimer’s disease. They first performed a genomewide association study (GWAS) in an ...
COMMENT This study is clearly of interest, supporting the idea that a lower plasma Aβ42 to Aβ40 ratio (i.e., a higher Aβ40 to Aβ42 ratio in this study) may be associated not only with an increase in risk of developing dementia, as previously described by us and ...
COMMENT By Jean-Charles Lambert and Philippe Amouyel We conducted a GWAS in 2,032 AD cases and 5,328 controls from the prospective population-based 3C study. We next replicated our most interesting hits in independent collections from Belgium, Finland, Italy and ...
