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Jean-Charles Lambert on Epigenomic Roadmap Points to Causal Genes

COMMENT This work has several objectives: (i) to establish a systematic mapping of transposase-accessible chromatin (ATAC) regions in seven brain regions from 39 healthy individuals; (ii) from some of the samples used in the previous bulk assay, to perform a ...

Jean-Charles Lambert on Lack of BIN1 Sows Tau Trouble for Neurons

COMMENT It is well accepted that knowledge of the genetic determinants of AD should improve our understanding of the fundamental disease processes. However, when identified, it is often difficult to understand how genetic variants mechanistically contribute to AD ...

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