5 RESULTS
COMMENT I was greatly saddened to hear of Peter’s passing. He was a Goliath in the Alzheimer’s field, and he leaves an enduring legacy. I deeply admired and respected his science and personality. Although he might be considered dogmatic, I always found him to be ...
COMMENT This study, executed by Dr. Bettina Platt's laboratory, is an important step toward understanding the role of human BACE1 in Alzheimer’s disease. It is an elegant study that provides a better understanding of the physiological role of human BACE1. In ...
COMMENT Winton et al. use histochemistry and a variety of antibodies to conclude that the 3xTg-AD mice lack intracellular Aβ. This study also uses a genetic approach to conclude that Aβ does not modulate tau pathology in 3xTg-AD mice. We find that the data ...
COMMENT This paper provides solid support for the idea that BDNF can regulate SORLA expression via ERK activation. It presents interesting findings showing that BDNF, acting via SORLA, can decrease Aβ generation in wild-type mice and primary neurons. This is a ...
COMMENT More evidence suggesting that AD is associated with aberrant cell cycle events (CCEs), which appears to be linked to Abeta oligomers, and blocking beta-secretase appears to diminish the CCEs. laferla 0 ...
