Kenneth Kosik on Islands of Tau Coat and Protect Cytoskeleton

COMMENT Phase states of tau can regulate microtubule function These new tau papers advance our knowledge of tau protein function at a mechanistic level. Previous work showed that tau is an RNA-binding protein capable of undergoing liquid-liquid phase separation ...

Kenneth Kosik on Tau Droplets Sprout Microtubules

COMMENT Liquid-liquid phase separation (LLPS) of intrinsically disordered, low-complexity proteins is a widespread biophysical phenomenon, and recently has been extended to include the microtubule binding protein tau. The most pressing and unresolved questions ...

Kenneth Kosik on More Droplets of Tau

COMMENT Tau Packs Heat No doubt tau protein is the culprit in its namesake diseases—the tauopathies, which include Alzheimer’s disease. Among the longstanding head-scratching problems in tau pathobiology is how tau, one of the most soluble proteins known, ...

Kenneth Kosik on ‘Godfather of Tau’ Skip Binder Dies at 63

COMMENT Irreverent, witty, lively, and always full of kindness and generosity, Skip’s untimely death must give pause to all of us who knew him, and many more who only knew of him. We should build upon his insights as we delve ever more deeply into the diseases ...

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