9 RESULTS
COMMENT Increasingly, the lysosome is becoming the centerpiece for understanding the cell biology of inclusion body neurodegenerative diseases. The fascinating paper by Cuddy et al. adds an intricate layer of regulation over lysosomal activation in the context of ...
COMMENT Phase states of tau can regulate microtubule function These new tau papers advance our knowledge of tau protein function at a mechanistic level. Previous work showed that tau is an RNA-binding protein capable of undergoing liquid-liquid phase separation ...
COMMENT Liquid-liquid phase separation (LLPS) of intrinsically disordered, low-complexity proteins is a widespread biophysical phenomenon, and recently has been extended to include the microtubule binding protein tau. The most pressing and unresolved questions ...
COMMENT Tau Packs Heat No doubt tau protein is the culprit in its namesake diseases—the tauopathies, which include Alzheimer’s disease. Among the longstanding head-scratching problems in tau pathobiology is how tau, one of the most soluble proteins known, ...
COMMENT Irreverent, witty, lively, and always full of kindness and generosity, Skip’s untimely death must give pause to all of us who knew him, and many more who only knew of him. We should build upon his insights as we delve ever more deeply into the diseases ...
COMMENT The NIH State-of-the-Science Conference has set a threshold of evidence required to make recommendations that goes beyond what would best serve the interests of public health. This may seem paradoxical, because as scientists we demand the highest ...
COMMENT The API project is important and valid, but I'd like to point out one oversight in this story. While the two study populations targeted at present are primarily selected on the basis of genetic risk, the non-genetic risk factors for AD, such as ...
COMMENT This paper by Dickey et al. is a strong addition to mounting evidence that phosphorylated tau is a dangerous moiety. One way the neuron protects itself from this danger is to call upon CHIP, Hsc70, and ubiquitin to modify tau in a manner that may ...
COMMENT The cell fusion looks really interesting, especially considering (1) the challenge of getting cellular models of AD, (2) the great number of constructs that need analysis, and (3) the otherwise difficult analysis of gene dosage. kosik 0 ...
