Gernot Kleinberger on Cut Loose, Soluble TREM2 Beckons Microglia to Mop Up Plaques
COMMENT TREM2 is a type-I transmembrane protein that can undergo proteolytic shedding to release its Ig-like domain as a soluble protein, termed sTREM2, into the extracellular space. It can be readily detected in biological fluids, including the cerebrospinal ...