5 RESULTS
COMMENT TREM2 is a type-I transmembrane protein that can undergo proteolytic shedding to release its Ig-like domain as a soluble protein, termed sTREM2, into the extracellular space. It can be readily detected in biological fluids, including the cerebrospinal ...
COMMENT Recent advances in the methodology of deriving macrophages and microglia-like cells from induced pluripotent stem cells (iPSCs) has opened up new opportunities to functionally characterize the effects of disease-associated variants (e.g. TREM2, CD33 …) ...
COMMENT These are really exciting days, with increasing numbers of very interesting and informative studies on the function of TREM2 in the context of Alzheimer’s disease. Following an earlier study by the Colonna lab (Song et al., 2018), Lee and colleagues ...
COMMENT In this extremely exciting paper, the Colonna lab shows that TREM2-deficient, dysfunctional microglia can be therapeutically modulated to regain their original defense mechanisms. Ulland and colleagues show this by restoring energy supply via stimulation ...
COMMENT This is exciting news—more and more evidence is now provided for a causative role of microglial dysfunction in Alzheimer's disease and other neurodegenerative disorders. Strikingly, this paper not only confirms an AD-associated TREM2 variant in a ...
