5 RESULTS
COMMENT In our paper (Jackson et al., 2015), we measured endogenous levels of TDP-43 mRNA to address auto-regulation. We also carefully studied whether co-expressing two transgenes with AAV resulted in non-specific gene competition. The data in the paper support ...
COMMENT This is an exciting and potentially very important new model system for C9 forms of ALS and FTLD. The paper underscores the utility of somatic cell gene transfer with AAV vectors for disease modeling. The vector approach is rapid and therefore expedites ...
COMMENT The nanoparticle gene transfer described by Bharali et al. is an exciting new avenue for genetic modification in the brain. The study suggests the organically modified nanoparticles are easy to make, are safe, and provide efficient and widespread ...
COMMENT The findings by Kirik et al. are a breakthrough because they provide a human-like model of Parkinson's disease and make the earlier findings in rats (Kirik et al., 2002; Lo Bianco et al., 2002; Klein et al., 2002) even more relevant for Parkinson& ...
COMMENT While the germline transgenic approach is the gold standard for studying gene function in the brain, it is also labor-intensive, expensive, and requires long periods of time to screen and raise the animals. We have adopted an alternative somatic ...
