5 RESULTS
COMMENT A recent study by Ghoshal and her colleagues may be of interest here. In this study, the authors reported that numerous Aβ plaques were co-distributed with spongiform degeneration. kim.jungsu 0 Codistribution of amyloid beta plaques and spongiform ...
COMMENT To test if a retinoic acid can reduce amyloid deposition in vivo, the authors used the APPswe/PS mutant transgenic mouse model. It is unclear to me which mouse model was used in the current study. Although it was stated in the text that line85 APPswe ...
COMMENT MicroRNA and Proteome Change In this study, Baek et al. used a quantitative proteomics approach (i.e., “conventional” SILAC method) to analyze the proteome changes induced by the overexpression and knockout of several miRNAs. Interestingly, authors ...
COMMENT In this study, Wikoff et al. utilized non-biased metabolomics approaches to investigate CSF metabolome changes in SIV-infected monkeys. The authors reported that the levels of several specific carnitines, fatty acids, and lysophosphatidylcholines were ...
COMMENT This work clearly demonstrates the importance of targeting to the right subcellular localization in the inhibition of BACE. To test if a BACE inhibitor can reduce Aβ production in vivo, the authors used the APPswe/PS mutant transgenic mouse model. It is ...
