7 RESULTS
COMMENT The effects of Alzheimer’s pathology on brain vasculature is an important topic and this study demonstrates that vascular endothelial disruption and the breakdown of the BBB is influencing cognitive performance independent of Alzheimer’s-related pathology ...
COMMENT This paper adds to the growing literature on amyloid and tau pathological processes in Lewy body diseases by focusing on patients with Parkinson’s disease with normal cognition or with mild cognitive impairment. Findings suggest that Alzheimer’s pathology ...
COMMENT This is a well-designed study to evaluate the risk of AD dementia and dementia in general in MCI patients, using biomarkers. The cohort of MCI patients was recruited from memory clinics and followed up to three years. Time-dependent analyses reveal the ...
COMMENT I think excellent work is emerging from the IDEAS study. The findings will likely have a significant impact on clinical practice for amyloid imaging and perhaps set the stage for similar studies involving other upcoming AD biomarkers. It will be important ...
COMMENT The paper by Gomperts et al. is an important investigation of AV-1451 binding in Lewy body dementias. Accumulation of tau pathology in patients with DLB has been recognized through autopsy studies. The study demonstrates that tau deposition is present in ...
COMMENT That [18F]-T807 uptake in FTLD syndromes co-localizes with structural changes seen on MRI scans demonstrates the sensitivity of this PET ligand for the pathology of FTLD. This finding has implications for early diagnosis as well as for tracking disease ...
COMMENT The study by Kantarci et al. investigating the focal hemosiderin deposits in the form of microhemorrhages and superficial siderosis in the ADNI cohort (Kantarci et al., 2013), reported that a majority of individuals with superficial siderosis also have ...
