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Fuyuki Kametani on Presenilin Loss of Function—Plan B for AD?

COMMENT Shen and Kelleher offer a very interesting hypothesis. I have reported that AICDε (C50) is preferentially produced from the α-secretase product C83, not from C89 and C99, indicating that γ-site cleavage and ε-site cleavage are regulated differently (Kume ...

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