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Mathias Jucker on Are Microglia Plaque Factories?

COMMENT This nice study by Green’s group investigates what happens after elimination of microglia in the 5xFAD mouse model. The hypothesis they propose, i.e., that microglia take up Aβ and form fibrils, is interesting but not novel. Wisniewski and others came to ...

Mathias Jucker on Like Prions, Tau Strains Are True to Form

COMMENT This is a very carefully done and exciting study that convincingly demonstrates the existence of tau conformers ("strains") in living systems. In vivo strains have been suggested previously for tau (e.g., Clavaguera et al., 2013), synuclein (e.g ...

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