4 RESULTS
COMMENT Ever since Anne Cataldo and Ralph Nixon and their many coworkers (one article was cited above) advanced this line of research over 30 years ago, it has been very clear that lysosomal trafficking is critical to the pathology of Alzheimer's disease. ...
COMMENT A great deal of preclinical work in gene therapy for diverse neurological diseases has been conducted over the past 20 years. The technologies for both antisense and viral-vector-based delivery are finally becoming mature, and without a doubt will be ...
COMMENT Viral-vector-based gene therapy has had emerging success stories in a number of neurological applications, especially for monogenic rare diseases. The trick with Alzheimer's disease (a complex disorder) will be targeting the most high-impact genes at ...
COMMENT This phenomenon was reported many years ago by Tsunao Saitoh, Eliezer Masliah, and other investigators. Papers going back to the 1990s had reported a "Non-Amyloid Component of Plaque" (NACP), which was actually α-synuclein. This comprised as ...
